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What is the tablet used to reduce weight? Oral Semaglutide #bestdiabetologistinkolathur #weightloss

Semaglutide is a GLP 1 analogue primarily used in weight loss and also in glycemic management.

It usually comes in the brand names of Wegovy, Ozempic and Rybelsus

Apart from its use in weight loss and in the management of type 2 diabetes mellitus it is also used for reducing the cardiovascular risk in persons with diabetes.

Mechanism of action

It acts by stimulating insulin release when the blood glucose level is high. It also acts by decreasing the liver gluconiogenesis. It decreases the gastric emptying time and also. improves the satiety, hence is helpful in the weight loss in long term.

Side effects

The most common side effect is related to GI tract and it includes nausea, vomiting, diarrhoea, constipation, abdominal pain and myalgia
Rare side effects include pancreatitis, renal compromise, thyroid cancer (Medullary thyroid carcinoma)
Contraindications: Family history of thyroid cancer or those with multiple endocrine neoplasia (MEN 2) type 2.

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