Hyperbaric oxygen therapy is a therapeutic modality that involves administering 100% oxygen at pressures, exceeding atmospheric pressure, typically ranging from 2.0 to 2.5 atmosphere absolute within a pressurize to chamber.
This increased ambient pressure allows for a significant elevation of oxygen , dissolved in plasma independently of hemoglobin bound oxygen,there by markedly enhancing oxygen delivery to hypoxic or ischemic tissues.
The treatment is delivered in sessions lasting approximately 90 to 120 minutes usually once or twice daily, over several weeks depending on clinical response and wound severity
Hyperbaric oxygen therapy has gained recognition as an adjunctive treatment for chronic non healing diabetic foot ulcers which represent a major source of morbality and healthcare burden globally.
Diabetic foot ulcers frequently result from a combination of peripheral neuropathy, ischemia due to peripheral arterial disease and impaired immune responses characteristic of diabetes mellitus
These pathophysiological features often lead to tissue hypoxia ,delayed wound healing and an increased risk of infection and subsequent amputation.
The mechanism and effects of hyperbic oxygen therapy include increased tissue oxygenation, angiogenesis stimulation ,enhanced leukocyte activity, fibroblast activation ,osteogenesis support and anti inflammatory modulation.
This increased ambient pressure allows for a significant elevation of oxygen , dissolved in plasma independently of hemoglobin bound oxygen,there by markedly enhancing oxygen delivery to hypoxic or ischemic tissues.
The treatment is delivered in sessions lasting approximately 90 to 120 minutes usually once or twice daily, over several weeks depending on clinical response and wound severity
Hyperbaric oxygen therapy has gained recognition as an adjunctive treatment for chronic non healing diabetic foot ulcers which represent a major source of morbality and healthcare burden globally.
Diabetic foot ulcers frequently result from a combination of peripheral neuropathy, ischemia due to peripheral arterial disease and impaired immune responses characteristic of diabetes mellitus
These pathophysiological features often lead to tissue hypoxia ,delayed wound healing and an increased risk of infection and subsequent amputation.
The mechanism and effects of hyperbic oxygen therapy include increased tissue oxygenation, angiogenesis stimulation ,enhanced leukocyte activity, fibroblast activation ,osteogenesis support and anti inflammatory modulation.
