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Neonatal Diabetes is a rare monogenic form of Diabetes discovered during the first six months of life affecting around 1 in 1,00,000 to 3,00,000 new borns It causes severe hyperglycemia due to insufficient insulin production. NDM can be permanent or transient, and is treated based on genetic causes, often with sulfonylurea pills instead of insulin .
neonatal diabetes
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Neonatal diabetes mellitus (NDM) is a rare, monogenic form of diabetes diagnosed within the first 6 months of life, affecting 1 in 100,000 to 300,000 newborns. It causes severe hyperglycemia due to insufficient insulin production. NDM can be permanent or transient, and is treated based on genetic causes, often with sulfonylurea pills instead of insulin.
Key Aspects of Neonatal Diabetes
Types:
Permanent (PNDM): Requires lifelong treatment.
Transient (TNDM): Often resolves within a few months but may relapse later.
Causes: Unlike Type 1 diabetes, which is autoimmune, NDM results from genetic mutations that impair pancreatic beta-cell development or function. Over 85% of cases can be diagnosed via genetic testing.
Symptoms: High blood sugar (hyperglycemia), severe dehydration, failure to thrive (poor weight gain), and sometimes absent or low insulin levels.
Treatment:
Sulfonylureas: Many patients with mutations in the KCNJ11 or ABCC8 genes can switch from insulin injections to oral medication, which often results in better blood sugar control and neurological outcomes.
Insulin: Necessary for other forms of the disease.
Prognosis: Early diagnosis and genetic testing are crucial for selecting the correct treatment
Bus Stand, Dr Antony's Cardio Diabetic Centre, 7/158, 15th street, Jagannathan Salai, opposite to Periyar Nagar, Periyar Nagar West, Perambur, Chennai, Tamil Nadu 600082
600082
Chennai
India
08042781449
Dr Antony's Cardio Diabetic Centre
https://www.drantonyscardiodiabeticcentre.com
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